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The implications of HPV in preterm birth PowerPoint Presentation

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Description : The International Committee on Taxonomy of Viruses has classified the PVs into 53 genera, among which only 5 genera include PVs that infect humans (HPVs): alpha, beta, gamma, mu, and nu. The genus gamma includes the majority of the known HPVs, with 99 types, followed by the genera alpha and beta. In order to be classified as a new PV type, there must be a less than 90% DNA base-pair homology with other PVs. During the past decade, there has been an exponential increase in the identification of new beta- and gamma-HPVs that have been discovered by next-generation sequencing. More than 200 different HPV types have been listed by the International HPV Reference Center, and this number continues to expand. A recent study reported the identification of the complete genome of 83 previously unknown HPV types, among which 69 were classified as gamma.

Tags : Irina Matache

Published on : Sep 29, 2020 | Views : 934 | Downloads : 4

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Slide 1-

THE INVOLVEMENT OF HPV (Human Papillomavirus) INFECTION IN PREMATURE BIRTHS Irina Mihaela Matache 1,2 Dragos Cretoiu1,2 Florentina Duică 2 1 Carol Davila University of Medicine and Pharmacy, Bucharest, Romania 2 National Institute of Mother and Child Health, Bucharest, Romania
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What is HPV? Papillomaviridae – an ancient taxonomic family of non-enveloped DNA viruses > 200 types of HPV have been identified, belonging to 5 major genera 83 types have been completely sequenced https://www.medicaldevice-network.com/news/institut-pasteur-cervical-cancer-test/
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https://www.nature.com/articles/488S2a?platform=oscar&draft=collection
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Preterm Birth -Key Facts- Before 34 completed weeks – early preterm Between 34 and 36 completed weeks – late preterm Between 37 weeks, 0 days and 38 weeks, 6 days – early term Every year, an estimated 15 million babies are born too early, and this number is rising https://www.womanlymag.com/black-maternal-health/need-to-know-preterm-birth
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Mechanisms of Preterm Birth https://www.bmj.com/content/329/7467/675
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Can HPV infection be linked to an increased risk of preterm birth?
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HPV and the Placenta Vertical transmission of HPV is possible during: 1. fertilization 2. pregnancy (prenatal) 3. delivery (perinatal) Prenatal transmission: presence of HPV in placenta and/or in cord blood => increased risk of newborn infection Placenta plays an important role in the transmission of HPV and other human viruses
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Endometrial HPV Infection Initial infection of the endometrium is cleared by regular menstrual shedding. Lack of menstrual shedding, endometrial decidualization during pregnancy contributes to HPV persistence and growth. Pregnancy has previously been described as a state of immune suppression, facilitating the survival of the fetus but also increasing the susceptibility to HPV and making it more difficult to clear HPV infections. Endometrium could represent a reservoir of HPV infection.
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Ambühl LMM et al., Infect Dis Obstet Gynecol, 2016 HPV prevalence appears to be highly dependent on the tissue type tested
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HPV prevalence higher in pregnancies with adverse outcome compared to normal pregnancies
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112 cervico-vaginal samples from 3 groups of people: first group - pregnant women (7-10 weeks of gestation) second group - mothers who gave birth at term third group - mothers of premature newborns.
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Results
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This study is part of a project PN-III-P1-1.2-PCCDI-2017-0820, MiMoSa The main purpose of this project is the development of a microarray platform using gold structures. This will be utilized for the specific detection (through fluorescence and SPR) of HPV strains in pregnant women. The obtained information will facilitate the statistical evaluation of the involvement of HPV infection in premature births.
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Conclusion
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Thank you!

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