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Ocular Pharmacology II PowerPoint Presentation

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Description : Check out this medical PowerPoint presentation titled "Ocular Pharmacology II” by Dr.Ajai Agrawal.

This medical PowerPoint presentation is about therapeutic agents for glaucoma, anti-inflammatory agents, tear substitutes, drugs and biological agents used in ophthalmic surgery and ocular toxicology.

Tags : Ocular Pharmacology, eye diseases, eye disorders, Ophthalmology, Ophthalmology PowerPoint presentation

Published on : Jun 20, 2023 | Views : 644 | Downloads : 2

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Slide 1-

Ocular Pharmacology -II Dr. Ajai Agrawal Additional Professor Department of Ophthalmology A.I.I.M.S., Rishikesh
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Learning Objectives At the end of this class students shall have a basic understanding of : Therapeutic agents for glaucoma Anti-inflammatory agents Tear substitutes Drugs and biological agents used in Ophthalmic surgery Ocular toxicology
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Overview
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Agents used for treatment of Open angle Glaucoma Prostaglandin analogues Beta receptor antagonists Alpha receptor agonists Carbonic anhydrase inhibitors
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Prostaglandin Analogs First- line medical therapy for Glaucoma PGF2α analogs - Good efficacy Once daily application Absence of systemic side effects 1.Latanoprost 2. Travoprost 3.Bimatoprost Facilitate aqueous outflow through uveoscleral outflow pathway
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Prostaglandin Analogs Side effects Ocular irritation & pain Blurring of vision Increased iris pigmentation Macular edema
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β Adrenergic blockers Nonselective β blockers – Timolol maleate - Levobunolol - Metipranolol - Carteolol β -1 antagonist - Betaxolol
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Mechanism of Action of β Blockers Lower IOP by reducing aqueous formation -- Down regulation of adenylylcyclase due to β2 receptor blockade in ciliary epithelium -- Reduction in ocular blood flow
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Adverse Effects of Ocular β Adrenergic blockers Ocular Stinging, redness & dryness of eye Corneal hypoesthesia Allergic blepharoconjunctivitis Blurred vision Systemic Bronchospasm in asthmatics & COPD patients Bradycardia & accentuation of Heart block Minimization of systemic adverse effects
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Alpha Adrenergic agonists Brimonidine (Alpha-2 agonist)(0.1%,0.2%) Usually used as an add on agent Mainly reduces aqueous production Also increases uveoscleral outflow To be used cautiously in children and elderly as it may cause fatigue and drowsiness.
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Carbonic anhydrase Inhibitors (CAI) Systemic -Acetazolamide Topical CAI – Dorzolamide , Brinzolamide Inhibits carbonic anhydrase (isoenzyme II) on ciliary body epithelium → Reduces formation of bicarbonate ions → Reduces fluid transport → Reduces aqueous formation → Decrease IOP Use – Only as add on drug to topical β blockers or PG analogs Systemic CAI – Final medication option before resorting to laser or incisional surgical treatment
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Carbonic anhydrase Inhibitors (CAI) Side effects Paresthesia Frequent urination GI disturbances Hypokalemia
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Topical Miotics Only of historical importance in open angle glaucoma - Ciliary muscle contraction - Increase drainage through trabecular meshwork Drug----Pilocarpine 1,2,4%. Less useful drug – Numerous side effects & three to four times a day dosing
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Stepped Medical Approach to Treatment of Open Angle Glaucoma
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Angle closure Glaucoma Hypertonic Mannitol ( 20%) IV infusion 1.5 -2 g/kg 2. Acetazolamide - 0.5 g oral 3. Miotic - Pilocarpine (1-4%) 4. Timolol 0.5 % - instilled 12 hourly. Definitive treatment – Surgical/ Laser iridotomy
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stimulus Phospholipase A2 Lipoxygenases Leukotrienes Steroids NSAIDS
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Corticosteroids CLASSIFICATION Short acting Hydrocortisone, Cortisone, Prednisolone Intermediate acting Triamcinolone, Fluprednisolone Long acting Dexamethasone ,Betamethasone
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Therapeutic Uses of Topical steroids Significant ocular allergy Anterior uveitis Postoperative inflammation following refractive, corneal & intraocular surgery To reduce potential scarring of surgical site (After Glaucoma filtering surgery ) NEVER GIVE STEROIDS IF YOU ARE SUSPECTING ACTIVE INFECTION
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Steroids in ocular conditions…… Systemic steroids & by sub-Tenon’s capsule injection – Posterior Uveitis Intravitreal injection – -- Age-related Macular degeneration (ARMD) -- Diabetic Retinopathy -- Cystoid Macular Edema (CME) Parenteral steroids followed by tapering oral doses – Optic Neuritis
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ALLERGIC CONJUNCTIVITIS
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SCLERITIS
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ANTERIOR UVEITIS
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OPTIC NEURITIS
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Toxicity of Steroids Posterior subcapsular cataracts Secondary infections Secondary open-angle glaucoma 4. Delayed wound healing “ Soft steroids (e.g., Loteprednol ) reduce the risk of elevated IOP ”
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SYSTEMIC side effects of steroids Peptic ulcer Hypertension Increased blood sugar Osteoporosis Mental changes Activation of tuberculosis and other infections
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Topical NSAIDs & their Ocular Uses
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Tear Substitutes Hypotonic or isotonic solutions – Eg: Carboxymethylcellulose Polyvinyl alcohol Polyethylene and propylene glycol Indications Ocular irritation in various diseases Dry eye disease
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Therapeutic Uses of Tear Substitutes Ocular diseases – Allergic conjunctivitis - Blepharitis - Corneal dystrophies - Chemical Burns Systemic diseases – Sjogren’s syndrome - Rheumatoid arthritis - Vitamin A deficiency - Stevens-Johnson syndrome
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Immunosuppressive & Antimitotic Agents Agents commonly used – 1. 5-fluorouracil 2. Mitomycin C Used In Glaucoma surgery, to improve success of filtration surgery by limiting postoperative wound-healing process. In corneal surgery, to reduce risk of scarring after excision of pterygium
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Immunomodulatory Agent Topical Cyclosporine – Approved for the treatment of chronic dry eye associated with inflammation -Decreases inflammatory markers in lacrimal gland & increases tear production
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Ocular diagnostic drugs Fluorescein dye Available as drops or strips Uses: To stain corneal abrasions applanation tonometry detecting wound leak fluorescein angiography Caution: Stains soft contact lens Fluorescein drops can be contaminated by Pseudomonas sp.
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Ocular diagnostic drugs Rose bengal stain Stains devitalized epithelium Uses: severe dry eye, herpetic keratitis
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Anaesthetics In Ophthalmic Procedures Proparacaine & tetracaine drops – Uses – Tonometry Gonioscopy Removal of foreign bodies, sutures on conjunctiva and cornea Adverse effects: toxic to corneal epithelium allergic reaction (rarely)
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Drugs & Biological Agents Used in Ophthalmic Surgery
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Botulinum Toxin Type A
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Ophthalmic Effects of Selected Vitamin Deficiencies & Zinc Deficiency
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Ophthalmic Effects of Selected Vitamin Deficiencies & Zinc Deficiency
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Ocular Toxicology
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Toxicology All opthalmic medications – Potentially absorbed into systemic circulation – Undesirable systemic side effects Eg. Timolol (single eye drop) - Death Local toxic effects – Hypersensitivity reactions -- Preservatives in eye drops & contact lens solutions – Benzalkonium chloride – Punctate Keratopathy Thimerosal – Hypersensitivity reactions
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Complications of topical administration Mechanical injury from the bottle e.g. corneal abrasion Pigmentation: epinephrine-adrenochrome Ocular damage: e.g. topical anesthetics, benzylkonium Hypersensitivity: e.g. atropine, neomycin, gentamicin Systemic effect: topical phenylephrine can increase BP
Slide 43-

Amiodarone A drug for treatment of cardiac arrhythmia Causes optic neuropathy (mild decreased vision, visual field defects, bilateral optic disc swelling) Also causes corneal vortex keratopathy (corneal verticillata) which is whorl-shaped pigmented deposits in the corneal epithelium
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Digitalis A drug for treating cardiac failure Causes chromatopsia (objects appear yellow) with overdose
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Chloroquines E.g. chloroquine, hydroxychloroquine Used in malaria, rheumatoid arthritis, SLE Cause vortex keratopathy (corneal verticillata) which is usually asymptomatic but can present with glare and photophobia Also cause retinopathy (bull’s eye maculopathy)
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Chorpromazine An antipsychotic drug Causes corneal punctate epithelial opacities, lens surface opacities Rarely symptomatic Reversible with drug discontinuation
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Thioridazine A psychiatric drug Causes a pigmentary retinopathy after high dosage
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Diphenylhydantoin An epilepsy drug Causes dosage-related cerebellar-vestibular effects: Horizontal nystagmus in lateral gaze Diplopia, ophthalmoplegia Vertigo, ataxia Reversible with discontinuation of the drug
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Topiramate A drug for epilepsy Causes acute angle-closure glaucoma (acute eye pain, redness, blurred vision, haloes). Treatment is by cycloplegia and topical steroids (rather than iridectomy) with the discontinuation of the drug
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HMG-CoA reductase inhibitors (statins) Cholesterol lowering agents E.g. pravastatin, lovastatin, simvastatin, fluvastatin, atorvastatin, rosuvastatin Can cause cataract in high dosages specially if used with erythromycin
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Ethambutol An anti-tubercular drug Causes a dose-related optic neuropathy Usually reversible but occasionally permanent visual damage might occur
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Systemic Agents with Ocular Side Effects
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Systemic Agents with Ocular Side Effects……..
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Visual field constriction Cataract
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Thank you