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Inflammatory Bowel Disease - Ulcerative colitis (UC) PowerPoint Presentation

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Description : Check out this medical presentation on Erythema Nodosum, which is titled "Inflammatory Bowel Disease - Ulcerative colitis (UC)", to know about Ulcerative colitis.

Tags : Erythema Nodosum, Inflammatory Bowel Disease, Ulcerative colitis

Published on : Jul 05, 2021 | Views : 1452 | Downloads : 16

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Inflammatory Bowel Disease Ulcerative colitis (UC) Kristina Blaslov Mentor: A. Žmegač Horvat
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Epidemiology Highest incidence in Europe, United Kingdom, North America
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Etiology and Pathogenesis Consensus hypothesis: genetically predisposed individuals + exogenous factors + host factors ↓ dysregulated mucosal immune function (modified by specific environmental factors )
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Pathology Macroscopic features: - mild inflammation - moderate disease - long-standing disease - fulminant disease
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Microscopic features -process limited to the mucosa and superficial submucosa, with deeper layers unaffected (except in fulminant disease!)
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Clinical presentation Signs and symptoms: - diarrhea - rectal bleeding - tenesmus - passage of mucus - abdominal pain - other symptoms: anorexia, nausea, vomiting, fever, weight loss
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Laboratory - rise in acute-phase reactants - erythrocyte sedimentation rate - decrease in hemoglobin - leukocytosis - pANCAs Endoscopy (not in acute phase!) - sigmoidoscopy - colonoscopy Radiology - barium enema
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Diagnosis relies on the patient's history, clinical symptoms, negative stool examination for bacteria, C. difficile toxin, and ova and parasites; sigmoidoscopic appearance and histology of rectal or colonic biopsy specimens!
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Extraintestinal manifestations: - dermatologic - erythema nodosum, pyoderma gangrenosum - rheumatologic - peripheral arthritis, ankylosing spondylitis - ocular - conjunctivitis, uveitis/iritis, episcleritis - hepatobiliary - steatosis, PSC - urologic - calculi, ureteral obstruction, fistulas - metabolic bone disorders - low bone mass
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Treatment
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Nutritional therapies : - total parenteral nutrition Surgical therapy - indications: intractable disease, fulminant disease, toxic megacolon, colonic perforation, massive colonic hemorrhage, colonic obstruction, colon cancer prophylaxis, colon dysplasia or cancer
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References: Harrison’s Principles of Internal Medicine, 17 th edition