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DIVISI TELINGA HIDUNG TENGGOROKAN – KEPALA LEHER DEPARTEMEN ILMU BEDAH FAKULTAS KEDOKTERAN UNIVERSITAS SAM RATULANGI Impact of surgical resection extension on outcome for primary well-differentiated thyroid cancer—a retrospective analysis EKANOVA RUTH NELLY SUMARAUW
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Surgical resection in combination with the possible adjunction of radioiodine therapy is the recommended standard treatment for well-differentiated thyroid cancer primary thyroid tumor total thyroidectomy or hemithyroidectomy has become standard over simple nodulectomy or subtotal resections, the issue of regional lymph node resection remains controversial therapeutic lymph node dissection when regional lymph node disease is proven or clinically suspicious is differentiated from prophylactic when no disease is identified preoperatively. The role of therapeutic neck lymph node dissection is well defined and should aim to clear involved compartments rather than removing simple affected lymph nodes Up to date, no clear impact of prophylactic lymph node dissection on improvement in recurrence rates or on survival rates has been shown. Some reports display a high rate of occult lymph node metastasis in prophylactic cleared compartments implicating a possible more accurate risk stratification for targeting of a potential adjuvant radioiodine treatment extended neck surgery comes along at an expense of higher surgery-related morbidity the variable adjunction of radioiodine therapy in these studies interpreting these data on oncologic outcomes should be undertaken cautious [9]. Therefore, one has to balance the oncologic outcome against postoperative complication and quality of life when choosing the optimal treatment extension for well-differentiated thyroid cancer. The aim of this study is to evaluate how the surgical resection extension with the adjunction of radioiodine therapy affects postoperative morbidity and the oncologic outcome (local and distant disease recurrence) of patients primarily treated for well-differentiated thyroid cancer. BACKGROUND 2
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A consecutive series of patients undergoing primary thyroid surgery for thyroid cancer from January 2005 to April 2013 at Tuebingen University Hospital was retrospectively analyzed using our electronic patient database. All patients with a histopathologic proven welldifferentiated thyroid cancer were included. Excluded were all cases of thyroid surgery for recurrent malignancy and cases where postoperative histopathological examination did not show any well-differentiated thyroid malignancy. Pre- and postoperative treatment recommendations were made on the discretion of an interdisciplinary board of surgeons, endocrinologists, and nuclear medicine according to the available treatment guidelines at that time. All thyroid specimens were histologically evaluated by a board-certified pathologist. Incidentaloma was defined as any postoperative established diagnosis of well-differentiated thyroid cancer in preoperative unsuspicious uni- or multinodular goiter patients. The following parameters were assessed: age, gender, final histopathologic diagnosis, suspicious cervical lymph nodes at preoperative sonography, local disease recurrence during follow-up, type of surgery, type of two stage completion surgery, and postoperative bleeding requiring redo surgery. Further, the number of adjuvant radioiodine therapies applied and cumulative dose of radioiodine were assessed. Postoperative biochemical hypocalcemia was defined as serum calcium below 2.0 mmol/l within 48 h. Persistent hypocalcemia was defined as serum calcium below 2.0 mmol/l and/or the need for supplementation with calcium and/or 1,25 OH vitamin D above 6 months after total thyroidectomy. Transient and permanent recurrent laryngeal nerve paralysis was defined as dysphonia for less than 6 and more than 6 months, respectively. The data was analyzed using SPSS Statistics 22 for Windows (IBM Corporation, NY, USA). The data are presented as absolute and relative numbers and median (range). Chi-squared test was performed for the comparison of surgery-related morbidity between one stage surgery patients and two-stage surgery patients. A p value less than 0.05 was considered to show differences of statistical significance. The study was approved by the local Ethics Review Board of the University of Tübingen, Germany. METHODS 3
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Patient histopathologic and surgical details are displayed in Table 1. Eighty-seven analyzed patients underwent total thyroidectomy in case of a differentiated thyroid cancer, 73 patients had a papillary thyroid cancer (PTC, including 27 patients with a papillary microcarinoma) and 14 patients a follicular thyroid cancer (FTC). Synchronous distant metastases were present in 12 patients (PTC, three of 73 patients (4%); FTC, nine of 14 patients (64%)). In three of these patients with FTC, the disease was diagnosed with an incidental finding of bone metastasis, while in the remaining nine patients, the synchronous metastases were detected during postoperative whole body scintigraphy directly after surgery. Fifty-six of the 87 patients (64.4%) underwent one stage surgery. Of these, 30 patients had no simultaneous lymph node dissection (LND) and 26 patients received simultaneous lymph node dissection. Furthermore, 31 patients (35.6%) underwent a two-stage completion surgery (2 patients with a completion thyroidectomy and 29 patients with a completion lymph node dissection with or without a completion thyroidectomy). In 22 out of 31 patients (71%), a two-stage completion surgery was performed after an incidentaloma was found in primary histopathology with preoperative unsuspicious cervical lymph nodes. Of the remaining nine patients, four patients showed a lymph node metastasis in the initial specimen, three patients had positive resection margins, and two patients displayed suspicious cervical lymph nodes in the pretest before radioiodine therapy (RAI). In 14 of 87 patients (16%), lymph nodes were rated to be suspicious for malignancy by ultrasound preoperatively. Of these, 10 of 14 patients displayed metastatic lymph nodes in the final histopathology (PTC, nine of 13 patients; FTC, one patient). Final histopathology showed lymph node metastasis in 21 out of the 87 patients (PTC, 20 of 73 patients (27%); FTC, one of 14 patients (7%). Of the 73 patients without preoperative suspicious cervical lymph nodes, 12 proved to have lymph node metastasis in final histopathology. Only in three patients a single lymph node metastasis (all below 2 mm) was newly detected during two-stage completion surgery (two patients with PTC and one with FTC). RESULTS 4
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5
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Patient histopathologic and surgical details are displayed in Table 1. Eighty-seven analyzed patients underwent total thyroidectomy in case of a differentiated thyroid cancer, 73 patients had a papillary thyroid cancer (PTC, including 27 patients with a papillary microcarinoma) and 14 patients a follicular thyroid cancer (FTC). Synchronous distant metastases were present in 12 patients (PTC, three of 73 patients (4%); FTC, nine of 14 patients (64%)). In three of these patients with FTC, the disease was diagnosed with an incidental finding of bone metastasis, while in the remaining nine patients, the synchronous metastases were detected during postoperative whole body scintigraphy directly after surgery. Fifty-six of the 87 patients (64.4%) underwent one stage surgery. Of these, 30 patients had no simultaneous lymph node dissection (LND) and 26 patients received simultaneous lymph node dissection. Furthermore, 31 patients (35.6%) underwent a two-stage completion surgery (2 patients with a completion thyroidectomy and 29 patients with a completion lymph node dissection with or without a completion thyroidectomy). In 22 out of 31 patients (71%), a two-stage completion surgery was performed after an incidentaloma was found in primary histopathology with preoperative unsuspicious cervical lymph nodes. Of the remaining nine patients, four patients showed a lymph node metastasis in the initial specimen, three patients had positive resection margins, and two patients displayed suspicious cervical lymph nodes in the pretest before radioiodine therapy (RAI). In 14 of 87 patients (16%), lymph nodes were rated to be suspicious for malignancy by ultrasound preoperatively. Of these, 10 of 14 patients displayed metastatic lymph nodes in the final histopathology (PTC, nine of 13 patients; FTC, one patient). Final histopathology showed lymph node metastasis in 21 out of the 87 patients (PTC, 20 of 73 patients (27%); FTC, one of 14 patients (7%). Of the 73 patients without preoperative suspicious cervical lymph nodes, 12 proved to have lymph node metastasis in final histopathology. Only in three patients a single lymph node metastasis (all below 2 mm) was newly detected during two-stage completion surgery (two patients with PTC and one with FTC). RESULTS 6
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In Table 2, the surgery-related morbidity is listed according to the surgical procedure. Patients with lymph node dissection at either one-stage and two-stage completion surgery had a significant higher rate of transient postoperative hypocalcemia. Furthermore, patients with a two-stage completion surgery had the tendency to more transient recurrent laryngeal nerve palsies. Postoperative RAI was performed in 68 of 87 patients (78%). The number of RAI performed varied from one to four with a cumulative dose of 3.8 GBq (range 1.9–28.9). The follow-up period was 69 months in median [range 9–104]. In the total cohort, local recurrence was documented in one patient 23 months after surgery. The patient suffered from a PMC, in whom already preoperatively lymph nodes were suspicious for malignancy in the central compartment, and this was confirmed by final histopathology. The therapy consisted of a thyroidectomy with central LND (first-stage surgery) and lateral LND (second-stage surgery) combined with a subsequent RAI. Two tumor-related deaths occurred in the follow-up period: one in a patient with FTC and synchronous bone metastasis and one in a patient with PTC (pT2) and synchronous lung and bone metastasis with a rapid progressive tumor disease who refused any further treatment after surgery. RESULTS 7
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Our results show that resected well-differentiated thyroid cancer with the adjunct of radioiodine therapy has a very low recurrence rate with only one local recurrence after a median follow-up time of 69 months. Well differentiated thyroid cancer and especially papillary thyroid cancer diagnosed postoperatively as incidentaloma are significantly increasing over the last decades [10]. This leads to the question if and if yes what kind of completion surgery is needed in these cases. Recommendations for the surgical treatment of well-differentiated thyroid cancer have undergone substantial changes in the past decade shifting to a more conservative approach than in the past [1]. While total thyroidectomy is regarded as standard for well-differentiated thyroid cancer of care for curative treatment, lobectomy for unifocal tumors smaller than 4 cm is gaining wider acceptance [11]. Further, there is a general consensus that cervical lymph node compartments should be cleared if clinically involved [1]. However, the prophylactic resection of lymph node compartments and even two-stage completion surgery in incidentaloma cases (e.g., completion thyroidectomy) is controversial [12, 13]. In general, lymphadenectomy of central compartment is associated with a higher morbidity, and any potential oncologic benefit must be balanced against permanent consequences like permanent hypoparathyroidism and palsy of the recurrent laryngeal nerve [14]. Therefore, an accurate and sensitive preoperative evaluation of the neck region is warranted. An ultrasound of the neck is currently regarded as the gold standard in the evaluation of local lymph nodes. However, preoperative ultrasound identifies only half of the lymph nodes found at surgery asking for strategies to improve diagnostic properties [15]. Further potential methods that might be considered in preoperative work up are 18FDG-PET scanning and also assessing distant disease status and sentinel lymph node sampling during surgery. While 18FDG-PET scanning is promising in the postoperative evaluation of patients with negative whole body iodine scan but Tg more than 10 ng/ml to localize occult disease or metastases, no clear evidence exists to support its general preoperative use for local lymph node evaluation [1, 16]. DISCUSSION 8
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Also, sentinel lymph node sampling during surgery seems to be feasible to detect metastasis. If selected nodal clearance of such detected lymph node metastasis results in improved prognosis remains open and needs to be further evaluated [17]. Concerning the risk of lymph node metastasis in welldifferentiated thyroid cancer, a review by Randolph et al. showed that the presence of clinically evident lymph nodes had an average risk of local recurrence of 22% compared with 2% for atients with clinically unsuspicious cervical lymph nodes regardless of surgical resection extension [18]. Clinically unsuspicious cervical lymph nodes are defined as findings that do not appear suspicious on physical examination or diagnostic imaging in the preoperative work up [19]. According to Ruel et al., clinically negative lymph node metastasis without extranodal extension can be regarded as a low-risk situation with no impact on patient survival [20]. They only reported a higher utilization rate of postoperative radioiodine therapy in these patients. Avoiding a central lymph node dissection in these cases might further decrease perioperative morbidity without loss of oncological benefit. In our series, neither lymph node metastasis nor a T4 tumor stage was associated with the presence of synchronous tumor dissemination. Only in three patients of our series a single lymph node metastasis was newly detected during two-stage completion surgery. Locoregional recurrence after limited surgery in a low-risk situation is described to be below 1%, all of them being managed successfully by surgical salvage therapy [21]. Additionally, evidence suggests that hemithyroidectomy is feasible for well-differentiated thyroid cancer smaller than 4 cm with no evidence of extrathyroidal extension or macroscopic lymph node metastasis with similar long-term survival and locoregional recurrence [11, 22]. An adjunct radioiodine therapy has been shown to improve long-term survival and locoregional recurrence in patients with structural and biochemical remnant disease [23]. However, the value of radioiodine therapy in low and intermediate risk cases according to the ATA has to be elucidated in further trials. DISCUSSION 9
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Altogether, completely resected well-differentiated thyroid cancer with the adjunct of radioiodine therapy has a very low recurrence rate. No prophylactic two-stage lymphadenectomy should be performed in case of well differentiated thyroid cancer with preoperative clinical unsuspicious cervical lymph nodes to avoid unnecessary complication without any proven oncologic benefit. CONCLUSION 10
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Haugen BR, Alexander EK, Bible KC, et al. 2015 American Thyroid Association management guidelines for adult patients with thyroid nodules and differentiated thyroid cancer: the American Thyroid Association guidelines task force on thyroid nodules and differentiated thyroid cancer. Thyroid. 2016;26(1):1–133. Dralle H, Musholt TJ, Schabram J, et al. German Association of Endocrine Surgeons practice guideline for the surgical management of malignant thyroid tumors. Langenbeck's Arch Surg. 2013;398(3):347–75. Zhao W, You L, Hou X, et al. The effect of prophylactic central neck dissection on locoregional recurrence in papillary thyroid cancer after total thyroidectomy: a systematic review and meta-analysis: pCND for the locoregional recurrence of papillary thyroid cancer. Ann Surg Oncol. 2017; 24(8):2189–98. Calo PG, Medas F, Pisano G, et al. Differentiated thyroid cancer: indications and extent of central neck dissection—our experience. Int J Surg Oncol. 2013;2013:625193. Zetoune T, Keutgen X, Buitrago D, et al. Prophylactic central neck dissection and local recurrence in papillary thyroid cancer: a meta-analysis. Ann Surg Oncol. 2010;17(12):3287–93. 6. Hartl DM, Leboulleux S, Al Ghuzlan A, et al. Optimization of staging of the neck with prophylactic central and lateral neck dissection for papillary thyroid carcinoma. Ann Surg. 2012;255(4):777–83. Popadich A, Levin O, Lee JC, et al. A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer. Surgery. 2011;150(6):1048–57. Ywata de Carvalho A, Chulam TC, Kowalski LP. Long-term results of observation vs prophylactic selective level VI neck dissection for papillary thyroid carcinoma at a cancer center. JAMA Otolaryngol Head Neck Surg. 2015;141(7):599–606. Lang BH, Ng SH, Lau LL, et al. A systematic review and meta-analysis of prophylactic central neck dissection on short-term locoregional recurrence in papillary thyroid carcinoma after total thyroidectomy. Thyroid. 2013;23(9):1087–98. DeSantis CE, Lin CC, Mariotto AB, et al. Cancer treatment and survivorship statistics, 2014. CA Cancer J Clin. 2014;64(4):252–71. Adam MA, Pura J, Gu L, et al. Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61,775 patients. Ann Surg. 2014; 260(4):601–5. Discussion 5–7 Kim SK, Woo JW, Lee JH, et al. Prophylactic central neck dissection might not be necessary in papillary thyroid carcinoma: analysis of 11,569 cases from a single institution. J Am Coll Surg. 2016;222(5):853–64. Nixon IJ, Wang LY, Ganly I, et al. Outcomes for patients with papillary thyroid cancer who do not undergo prophylactic central neck dissection. Br J Surg. 2016;103(3):218–25. Viola D, Materazzi G, Valerio L, et al. Prophylactic central compartment lymph node dissection in papillary thyroid carcinoma: clinical implications derived from the first prospective randomized controlled single institution study. J Clin Endocrinol Metab. 2015;100(4):1316–24. Leboulleux S, Girard E, Rose M, et al. Ultrasound criteria of malignancy for cervical lymph nodes in patients followed up for differentiated thyroid cancer. J Clin Endocrinol Metab. 2007;92(9):3590–4. Palaniswamy SS, Subramanyam P. Diagnostic utility of PETCT in thyroid malignancies: an update. Ann Nucl Med. 2013;27(8):681–93. Pelizzo MR, Merante Boschin I, Toniato A, et al. Sentinel node mapping and biopsy in thyroid cancer: a surgical perspective. Biomed Pharmacother. 2006;60(8):405–8. Randolph GW, Duh QY, Heller KS, et al. The prognostic significance of nodal metastases from papillary thyroid carcinoma can be stratified based on the size and number of metastatic lymph nodes, as well as the presence of extranodal extension. Thyroid. 2012;22(11):1144–52. Conzo G, Calo PG, Sinisi AA, et al. Impact of prophylactic central compartment neck dissection on locoregional recurrence of differentiated thyroid cancer in clinically node-negative patients: a retrospective study of a large clinical series. Surgery. 2014;155(6):998–1005. Ruel E, Thomas S, Perkins JM, et al. The impact of pathologically positive lymph nodes in the clinically negative neck: an analysis of 39,301 patients with papillary thyroid cancer. Ann Surg Oncol. 2017;24(7):1935–42. Kowalska A, Walczyk A, Palyga I, et al. The delayed risk stratification system in the risk of differentiated thyroid cancer recurrence. PLoS One. 2016;11(4):e0153242. Barney BM, Hitchcock YJ, Sharma P, et al. Overall and cause-specific survival for patients undergoing lobectomy, near-total, or total thyroidectomy for differentiated thyroid cancer. Head & Neck. 2011;33(5):645–9. Jonklaas J, Sarlis NJ, Litofsky D, et al. Outcomes of patients with differentiated thyroid carcinoma following initial therapy. Thyroid. 2006; 16(12):1229–42. REFERENCES 11