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Hydatidiform Mole PowerPoint Presentation

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Description : Check out this medical presentation on Gestational Trophoblastic Disease, which is titled "Hydatidiform Mole", to know about gestational trophoblastic disease.

Tags : Gestational Trophoblastic Disease, Hydatidiform Mole, Molar pregnancy, Choriocarcinoma, Placental-site trophoblastic tumor

Published on : May 18, 2021 | Views : 4460 | Downloads : 14

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Hydatidiform Mole Mamdoh Eskandar FRCSC
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Gestational trophoblastic Disease Molar pregnancy -Complete hydatiditform mole -Incomplete hydatiditform mole Choriocarcinoma Placental-site trophoblastic tumor
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Molar Pregnancy Complete mole - Fertilization an empty egg by one sperm. -All placental villa swollen. -Fetus, cord, amniotic membrane are absent. -Paternal chromosomes only. 46 XX. -diploidy Incomplete mole -fertilization of an egg by two sperms -some placental villa swollen Fetus, cord, amniotic membrane are present Paternal and maternal 69XXY -Triploid
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Molar Pregnancy Incidence and epidemiology: -In USA 1:1000 -In Asia 8:1000 Risk factors for molar pregnancy: -Extreme of age -Lower socioeconomic status -Race and ethnic origin -Blacks have lower incidence
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Molar Pregnancy Symptoms and signs of molar pregnancy -Abnormal bleeding in early pregnancy -Lower abdominal pain -Toxemia before 24 weeks of gestation -hyperemesis gravidarum
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Molar Pregnancy -Uterus large for dates -No fetal heart rate -Enlargement of the ovaries -Hyperthyroidism -Expulsion of swollen villi
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Molar Pregnancy Diagnosis: -Ultrasound shows snowstorm-like appearance, no fetus, theca lutein cyst -Beta hCG in normal pregnancy the level is at it peak at around 14 weeks (100,000 mIU/ml)
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TORONTO, CANADA, 1998, SANT.JOS. HOS.
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Management Once the diagnosis is made evacuation of the uterus should be done but prior to that: hCG preevacuation. Chest x-ray. Correct: anemia, toxemia, hyperthyroidism, pulmonary compromise.
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Follow up HCG weekly until normal for two values then monthly for one year. Repeat x- ray if HCG rises or plateau. Contraception for one year. Pelvic examination every 3 weeks for 3 months.
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Follow up Initiate chemotherapy if: -HCG level is increasing or plateaus -Metastasis disease is present -HCG level is still elevated after 6 months of evacuation -HCG starts to rise after being undetectable
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FICO Classification System of GTT I. Confined to corpus uteri II. Metastases to vagina or pelvic organs III. Metastases to lungs IV. Distant metastases
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Prognostic Classification of GTT I. Nonmetastatic GTT II. Metastatic GTT: disease outside the uterus. Good prognosis: Disease present less than 4 months Pretreatment HCG is less than 40,000 No prior chemothreapy No metastatic to the liver or the brain Poor prognosis: the opposite of good prognosis
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Thank you!