Download Free Medical Hematology PowerPoint Presentation

Hematology PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : bone cancer description

Tags : bone cancer

Published on : Dec 17, 2020 | Views : 8762 | Downloads : 19

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Department of Hematology & Oncology CHILD WITH LEFT FOREARM MASS Case presentation by Dr. M Fahim Ur rehman & Dr.shamaila rashid
Slide 2-

DEMOGRAPHY Usman S/O Nasir 8years old Resident of Gojra Presented through OPD CHF November, 2019
Slide 3-

History of Patient PRESENTING COMPLAINTS: Swelling on left forearm - 3weeks Pain in left forearm - 1week
Slide 4-

Cont. Pt was in his usual state of health when he noticed swelling in left upper part of forearm. Swelling was initially small then progressively increasing in size. H/O pain in left forearm for last 1week which was gradual in onset confined to upper part of forearm intermittent, dull in character moderate in intensity aggravated by movement and relieved by taking rest and medication.
Slide 5-

Cont. There was no H/O fever, wt. loss, loss of appetite, Bone Pains, Cough, Breathlessness, bleeding manifestation, headache, fits or altered sensorium. Previous history of injury of same side due to fall 2 years back and plaster of paris was applied due to bone dislocation for 3weeks at some private hospital .
Slide 6-

Cont. No H/O drug allergy. Delivered through NVD uneventful. Development milelstones appropriate for age. Vaccinated according to EPI. Diet was adequate. No family history of such illness, tuberculosis, he has four elder siblings all alive and healthy. He is student of 4th class, belongs to low socioeconomic status.
Slide 7-

EXAMINATION
Slide 8-

General Physical Examination A cooperative boy, well oriented in time and space with following vitals: - OFC 55cm Height:116cm Weight 26kg
Slide 9-

Cont. No pallor, cyanosis, jaundice clubbing, Bruises, BCG Scar Present. A lymph node of approx 1.5x0.5cm was palpable in left axilla. No other lymph node was palpable.
Slide 10-

Local Examination A swelling on left upper part of forearm of approx. 3x4cm firm in consistency,adherent to underlying structures,feels warm,non tender.
Slide 11-

Systemic examination Resp: NVB With no added sound CVS: S1 + S2 + 0 GTI: Soft Abdomen, No Visceromegaly CNS: Gcs 15/15 Tone / Power / Reflexes _ N All joints were normal and mobile with normal range of motion.
Slide 12-

Differential Diagonosis Fibroma due to trauma Bone cyst Osteomyelitis
Slide 13-

INVESTIGATIONS
Slide 14-

INVESTIGATIONS Hb 10.6g/dl WBC 12.4 X 10³/µ PLT 409 X10³/µ BLOOD UREA 18mg/dl SERUM CREATININE 0.6 mg/dl TOTAL BILIRUBIN 0.7mg/dl
Slide 15-

INVESTIGATIONS SGPT 39U/L SGOT 26U/L S/Na 140 mEq/L S/K 3.9 mEq/L S/Cl 102 mEq/L URIANANALIYSIS NORMAL ESR 20 C reactive protein 3mg/L
Slide 16-

CHEST X-RAY
Slide 17-

FOREARM X-RAY
Slide 18-

MRI FOREARM
Slide 19-

MRI FOREARM
Slide 20-

Cont. An ill defied mass lesion involving proximal shaft of left radius associated with tissue component and bony deformity measuring 31*25*55mm suggesting residual/recurrent diseases. It also shows bowing of shaft of proximal ulna and elbow joint is unremarkable.
Slide 21-

HISTOPATHOLOGY
Slide 22-

FISH
Slide 23-

Cont. After these investigations our diagnosis is EWING SARCOMA.
Slide 24-

STAGING WORK UP
Slide 25-

CT CHEST
Slide 26-

CT CHEST
Slide 27-

CTCHEST
Slide 28-

BONE SCAN
Slide 29-

BONEMARROY BIOPSY
Slide 30-

Echo Cardiography Structurally and functionally normal Echo study USG Abdome Normal Scan
Slide 31-

TREATMENT Chemotherapy Started In DEC.2019 According to EURO.EWING 99 protocols including 6 cycles of VIDE and 8 cycles of VAI. Surgery was done after initial 6 cycles and re-evaluation by orthopedic department in CHF where wide marginal resection and bone excision was done. Limb was saved . Treatment completed in Nov.2020 now Patient is completely well.
Slide 32-

Cont.
Slide 33-

Histopathology After surgery histopathology shows 90% necrosis and margins free of tumor. No lymph node found
Slide 34-

INTRODUCTION Ewing sarcoma was first described in 1921 by James Ewing. It belongs to Ewing family of tumors which include Ewing Saroma, Askin tumor and Peripheral Primitive neuro-ectodermal tumors. They shared same Physiology and Chromosomal translocation t(11;22). The most common mutation that causes Ewing Sarcoma involves two genes, EWSR1 gene on Chromosome 22 and the fL11 gene on Chromosome 11. It mostly affects long bone of legs (femur), flat bones (Pelvis and chest wall).
Slide 35-

ppt slide no 35 content not found
Slide 36-

Cont. It is the second most common primary bone tumor in children and accounts 2% of all childhood Lancers. It affects males more than females. Common between 10 and 20 years of age. The annual incidence is 2.93 children per 1,000,000. It is aggressive tumor and can spread to other bones, lungs and bone marrow.
Slide 37-

ppt slide no 37 content not found
Slide 38-

CLINICAL PRESENTATION Localized pain. Back pain due to Paraspinal retro peritoneal or deep pelvic tumor. Palpable mass. Systemic symptoms - fever, weight loss.
Slide 39-

SIGNS Careful inspection and palpation of painful sites. Neurological examination to evaluate asymmetrical weakness, numbness, pain. Skin inspection for petechie or purpura due to bone marrow involvement. Pulmonay auscultation for asymmetrical breath sounds pleural signs due to lung metastasis.
Slide 40-

DIAGNOSIS CBC Blood Cultuves C-reactive Rotein ESR LDH Cytogenetic and molecular studies. History
Slide 41-

Cont. Imaging of primary lesiob MRI Computed tomography If metastasis then Bone Marrow Biophy Chest C.T Scan Bone Scan Fluoro deoxglucose positron emission tomography (FDG - PET) scan
Slide 42-

MANAGEMENT Chemotherapy Neutrophil support Blood products Surgery and Radiotherapy
Slide 43-

Thank YOU