Download Free Medical Guideline for the Diagnosis and Management of Aortic Disease PowerPoint Presentation

Guideline for the Diagnosis and Management of Aortic Disease PowerPoint Presentation

DOWNLOAD MEDICAL POWERPOINT PRESENTATION

About This Presentation

Description : Check out this medical PowerPoint presentation titled "Guideline for the Diagnosis and Management of Aortic Disease".

This medical PowerPoint presentation lists Guideline for the Diagnosis and Management of Patients With Thoracic Aortic Disease adapted from 2022 ACC/AHA Guideline. This guideline is the most current, and it provides recommendations for the diagnosis and management of various types of thoracic aortic disease, including thoracic aortic aneurysms, thoracic aortic dissections, and thoracic aortic ulcerations.

Tags : Guideline for the Diagnosis and Management of Aortic Disease, Thoracic Aortic Disease, thoracic aortic aneurysms, thoracic aortic dissections, thoracic aortic ulcerations, Cardiothoracic Surgery, cardiology, cardiology PowerPoint presentation

Published on : Mar 19, 2023 | Views : 659 | Downloads : 6

Shareable Url :

Embed Code :

Comment

Transcript

Slide 1-

Clinical Update ADAPTED FROM: 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease
Slide 2-

Table Applying Class of Recommendation and Level of Evidence to Clinical Strategies, Interventions, Treatments, or Diagnostic Testing in Patient Care COR and LOE are determined independently (any COR may be paired with any LOE). A recommendation with LOE C does not imply that the recommendation is weak. Many important clinical questions addressed in guidelines do not lend themselves to clinical trials. Although RCTs are unavailable, there may be a very clear clinical consensus that a particular test or therapy is useful or effective. *The outcome or result of the intervention should be specified (an improved clinical outcome or increased diagnostic accuracy or incremental prognostic information). †For comparative-effectiveness recommendation (COR 1 and 2a; LOE A and B only), studies that support the use of comparator verbs should involve direct comparisons of the treatments or strategies being evaluated. ‡The method of assessing quality is evolving, including the application of standardized, widely-used, and preferably validated evidence grading tools; and for systematic reviews, the incorporation of an Evidence Review Committee. COR indicates Class of Recommendation; EO, expert opinion; LD, limited data; LOE, Level of Evidence; NR, nonrandomized; R, randomized; and RCT, randomized controlled trial. 2
Slide 3-

Aortic Anatomy Layers of the Aortic Wall Zones of the Aorta Aortic Aneurysm The standard definition of 1.5x expected diameter is not applicable to the root and ascending aorta, use > 4.5 cm for these segments For patients with height or BSA outside of 1-2 SD of the mean, use: Aortic size index [aortic diameter (cm) / BSA (m2)] Aortic height index [aortic diameter (cm)/ patient height (m)] Cross sectional area to height Abbreviations: BSA indicates body surface area; cm, centimeter; m, meter; and SD, standard deviation. 3
Slide 4-

Aortic Dissection Classification Classification Types of acute aortic syndromes Malperfusion 4
Slide 5-

Thoracoabdominal Aortic Aneurysm Classification Crawford Classification Predicts morbidity and mortality associated with aneurysm repair 5
Slide 6-

Thoracoabdominal Aortic Aneurysm Classification Endoleak Classification Endoleak = persistence of blood flow outside graft and within the aneurysm sac, preventing its complete thrombosis 6
Slide 7-

Imaging and Measurement for the Presence and Progression of Aortic Disease Abbreviations: CT, computed tomography; ECG, electrocardiogram; and MR, magnetic resonance. 7
Slide 8-

Diagnostic Performance of Aortic Imaging Modalities Legend +++ = excellent results ++ = good results + = fair results - = not available n/a = not applicable Abbreviations: CT indicates computed tomography; MRI, magnetic resonance imaging; TEE, transesophageal echocardiography; TTE, transthoracic echocardiography; and US, abdominal aortic ultrasound. 8
Slide 9-

Abbreviations: ECG indicates electrocardiogram. 9 Essential Elements of CT and MRI Aortic Imaging Reports
Slide 10-

Frequency of Surveillance Imaging of Abdominal Aortic Aneurysms Based on Current Aortic Diameter Abdominal Aortic Aneurysm 3.0 – 3.9 cm > 5.0 cm in men > 4.5 cm in women 4.0 – 4.9 cm in men 4.0 – 4.4 cm in women Imaging every 3y (Class 1) Imaging every 12 mo (Class 1) Imaging every 6 mo (Class 1) Abbreviations: cm indicates centimeter; mo, month; and y, year. 10
Slide 11-

Recommendations for Surgery for Sporadic Aneurysms of the Aortic Root and Ascending Aorta Symptomatic Asymptomatic Proceed to surgical repair (Class 1) Aneurysms of the aortic root or ascending aorta Diameter ≥5.5 cm Diameter <5.5 cm Maximum diameter of ≥5.0 cm Pt. height >1 SD above or below the mean and max. cross-sectional aortic area/height ratio of ≥10 cm2/m Aortic size index of ≥3.08 cm/m2 or aortic height index of ≥3.21 cm/m Confirmed rapid growth rate (≥0.3 cm/y over 2y OR ≥0.5 cm in 1y) Surgery is reasonable by experienced surgeons in a MAT (Class 2a) Surgery may be reasonable when performed by experienced surgeons in a MAT (Class 2b) Pt. undergoing repair or replacement of tricuspid AV with a concomitant aneurysm of the ascending aorta with max. diameter of ≥4.5 cm Ascending aortic replacement is reasonable by experienced surgeons in MAT (Class 2a) Pt. undergoing cardiac surgery for other than AV repair or replacement with aneurysm of the aortic root or ascending aorta and max. diameter of ≥5.0 cm Ascending aortic replacement may be reasonable (Class 2b) Abbreviations: AV indicates aortic valve; cm, centimeter; CT, computed tomography; y, year; MAT, multidisciplinary aortic team; max, maximal; pt, patient; SD, standard deviation; and y, year. 11
Slide 12-

Surgical Approach in Sporadic Aneurysms of the Aortic Root and AAA for Patients Meeting Surgery Criteria Key Take-Away The goal of prophylactic repair of aneurysms of the aortic root and ascending aorta is to prevent life threatening complications from acute aortic events such as AoD, aortic rupture, or sudden death. This goal is best achieved when the risk of future adverse aortic events is greater than the expected surgical mortality (considering both the surgeon’s and institutional experience). Abbreviations: AoD indicates aortic dissection; and MAT, Multidisciplinary Aortic Team. 12
Slide 13-

Recommendations for Aortic Arch Aneurysms Aortic arch aneurysm Symptomatic Asymptomatic Low or intermediate operative risk Low operative risk Open surgical replacement is recommended (Class 1) High surgical risk Open surgical replacement at an arch diameter of >5.5 cm is reasonable (Class 2a) Hybrid or endovascular approach may be reasonable (Class 2b) Considerations for Surgical Approach In patients undergoing open surgical repair for ….. an ascending aortic aneurysm an aortic arch aneurysm if the aneurysmal disease extends into the proximal aortic arch, it is reasonable to extend the repair with a hemiarch replacement (Class 2a) if the aneurysmal disease extends into the proximal descending thoracic aorta, an elephant trunk procedure may be considered (Class 2b) Abbreviations: cm indicates centimeter; and DTA, descending thoracic aneurysm. 13
Slide 14-

Guidance for Repair of Intact Descending Thoracic Aortic Aneurysms Descending thoracic aortic aneurysm repair thresholds <5.5cm Patients with average operative risk and elevated risk of rupture Risk factors for increased aneurysm rupture Growth ≥0.5cm/y Symptomatic Marfan or Loeys-Dietz syndrome HTAD Saccular aneurysm Female sex Mycotic aneurysm >5.5cm Patients with average operative risk and average risk of rupture >>5.5cm Patients with elevated operative risk and average risk of rupture Risk factors for increased operative morbidity Advanced age, particularly ≥75 y CKD3 or greater COPD and FEV1 <50% predicted Prior stroke Functional dependence Unfavorable anatomy for TEVAR Abbreviations: cm indicates centimeter; CKD, chronic kidney disease; COPD, chronic obstructive pulmonary disease; CT, computed tomography; FEV, forced expiratory volume; HTAD, heritable thoracic aortic disease; TEVAR, thoracic endovascular aortic repair; and y, year. 14
Slide 15-

Guidance for Repair of Thoracoabdominal Aortic Aneurysms Ruptured requiring intervention Intact requiring intervention Open repair is recommended (Class 1) Thoracoabdominal aortic aneurysm Hemodynamically stable Features associated with an increased risk of rupture,* repair is reasonable when the diameter is <5.5 cm (Class 2a) Endovascular repair may be reasonable in centers with endovascular expertise and access to appropriate endovascular stent grafts (Class 2b) Repair is recommended when the diameter is > 6.0 cm (Class 1) Repair is reasonable when the diameter is >5.5 cm and the repair is performed by experienced surgeons in a MAT (Class 2a) And suitable anatomy, endovascular repair with fenestrated stent grafts, branched stent grafts, or both may be considered in centers with endovascular expertise and access to appropriate endovascular stent grafts (Class 2b) In patients with Marfan syndrome, Loeys-Dietz syndrome, or vascular Ehlers-Danlos syndrome open repair is recommended over endovascular repair (Class 1) *Features Associated With Increased Risk of TAAA Rupture Rapid growth (confirmed increase in diameter of >0.5 cm/y) Symptomatic aneurysm Significant change in aneurysm appearance Saccular aneurysm or presence of penetrating atherosclerotic ulcers Abbreviations: cm indicates centimeter; CT, computed tomography; PAU, penetrating aortic ulcer; TAAA, thoracoabdominal aortic aneurysm; and y, year. 15
Slide 16-

Guidance for Repair of Abdominal Aortic Aneurysms Abdominal aortic aneurysm Ruptured Unruptured In the hemodynamic stable pt., CT imaging is recommended to evaluate whether the AAA is amenable to endovascular repair (Class 1) In the pt. with suitable anatomy, endovascular repair is recommended over open repair to reduce the risk of morbidity and mortality (Class 1) Local anesthesia is preferred to general anesthesia to reduce risk of perioperative mortality (Class 2a) Permissive hypotension can be beneficial to decrease the rate of bleeding (Class 2a) Repair is recommended in those with a maximal aneurysm diameter of >5.5 cm in men or >5.0 cm in women (Class 1) And saccular AAA, intervention to reduce the risk of rupture may be reasonable (Class 2b) Symptoms that are attributable to the aneurysm, repair is recommended to reduce the risk of rupture (Class 1) And aneurysm growth of >0.5 cm in 6 months, repair to reduce the risk of rupture may be reasonable (Class 2b) Abbreviations: AAA indicates abdominal aortic aneurysm; cm, centimeter; CT, computed tomography; and pt., patient. 16
Slide 17-

Surveillance Protocols Following Aneurysm Repair *Duplex US findings that should prompt additional axial imaging Aneurysm sac enlargement Any endoleak Stent graft fracture Stent graft migration Stent graft separation Abbreviations: CT indicates computed tomographic; EVAR, endovascular aortic repair; MRI, magnetic resonance imaging; TEVAR, thoracic endovascular aortic repair; and US, ultrasound. 17
Slide 18-

Acute Aortic Dissection: Malperfusion Treatment Options Acute Aortic Dissection Type A AoD Type B AoD Mesenteric or Renal Malperfusion Lower Extremity Ischemia Rupture Tamponade Stroke Mesenteric or Renal Malperfusion Lower Extremity Ischemia Rupture Tamponade Ascending Aortic Arch Surgery +/- antegrade TEVAR Endovascular fenestration Target Vessel Stenting Ischemia persists TEVAR +/- false lumen embolization Immediate Ascending Aortic/Arch Surgery Endovascular Fenestration TEVAR Ascending Aortic/Arch Surgery Extra-anatomic Bypass Abbreviations: AoD indicates aortic dissection; and TEVAR, thoracic endovascular aortic repair. 18
Slide 19-

Recommendations for Surgical Repair Strategies in Acute Type A Aortic Dissection Acute Type A Dissection Partially dissected root but no significant aortic valve leaflet pathology Without an intimal tear in the arch or a significant arch aneurysm Extensive destruction of the aortic root, a root aneurysm, or a known genetic aortic disorder In selected patients who are stable Dissection flap extending through arch into descending thoracic aorta Aortic valve resuspension is recommended over valve replacement (Class 1) Valve-sparing root repair may be reasonable, when performed by experienced surgeons in a MAT (Class 2b) Hemiarch repair is recommended over more extensive arch replacement (Class 1) Aortic root replacement is recommended with a mechanical or biological valved conduit (Class 1) An extended aortic repair with antegrade stenting of the proximal descending thoracic aorta may be considered to treat malperfusion and reduce late distal aortic complications (Class 2b) In patients with acute type A aortic dissection undergoing aortic repair, an open distal anastomosis is recommended to improve survival and increase false-lumen thrombosis rates. (Class 1) Abbreviations: MAT indicates Multidisciplinary Aortic Team. 19
Slide 20-

Recommendations for the Management of Acute Type B Aortic Dissection Acute Type B Dissection Uncomplicated Complicated High-risk anatomic features Other complications Rupture Endovascular management may be considered (Class 2b) Medical therapy as initial management (Class 1) If rupture or other complications, intervention recommended (Class 1) In the presence of suitable anatomy, the use of endovascular approaches, rather than open surgical repair, is reasonable (Class 2a) In the presence of suitable anatomy, endovascular stent grafting, rather than open surgical repair, is recommended (Class 1) 20
Slide 21-

Recommendations for Management of Intramural Hematoma Intramural hematoma Complicated Uncomplicated Acute type A or type B Type A Type B Urgent repair is recommended (Class 1) Selected patients who are at increased operative risk and do not have high-risk imaging features, initial or expectant medical management may be considered (Class 2b) Prompt open repair recommended (Class 1) Patients who require repair of the distal arch or descending aorta Favorable anatomy Medical therapy as the initial management strategy recommended (Class 1) If high risk imaging features,* intervention may be reasonable (Class 2b) Unfavorable anatomy Open surgery reasonable (Class 2a) Endovascular repair is reasonable (Class 2a) *High-Risk Imaging Features of IMH Abbreviations: IMH indicates intramural hematoma. 21
Slide 22-

Recommendations for Penetrating Atherosclerotic Ulcer and Type of Repair Penetrating atherosclerotic ulcer W/Rupture Isolated W/IMH Ascending Aorta Asymptomatic Symptomatic Aortic Arch/descending Aorta Abdominal Aorta Urgent repair recommended (Class 1) Repair recommended if pain clinically correlated with radiological findings (Class 1) Urgent elective repair may be consideredif high risk imaging features* (Class 2b) Urgent repair recommended (Class 1) Open surgical repair recommended (Class 1) Distal arch or descending aorta Urgent repair reasonable (Class 2a) Proximal arch Urgent repair may be considered (Class 2b) Either open surgical repair or endovascular repair is reasonable, based on anatomy and medical comorbidities** (Class 2a) *High-Risk Imaging Features of PAUs Maximum PAU diameter >13–20 mm Maximum PAU depth >10 mm Significant growth of PAU diameter or depth PAU associated with a saccular aneurysm PAU with an increasing pleural effusion **Medical Comorbidities Extensive and diffuse ASCVD in aorta and coronary arteries HTN Tobacco use COPD Renal insufficiency Connective tissue disorder Abbreviations: ASCVD indicates atherosclerotic cardiovascular disease; COPD, chronic obstructive pulmonary disease; HTN, hypertension; IMH, intramural hematoma; mm, millimeter; and PAU, penetrating atherosclerotic ulcer. 22
Slide 23-

Approach to the Initial Management of Blunt Traumatic Thoracic Aortic Injury Medical management Operative repair *High-Risk Imaging Features of BTTAI Posterior mediastinal hematoma >10 mm Lesion to normal aortic diameter ratio >1.4 Mediastinal hematoma causing mass effect Pseudocoarctation of the aorta Large left hemothorax Ascending aortic, aortic arch, or great vessel involvement Aortic arch hematoma Abbreviations: BTTAI indicates blunt traumatic thoracic aortic injury f/u, follow-up; and mm, millimeter. 23
Slide 24-

Approach to the Initial Management of Blunt Traumatic Abdominal Aortic Injury Treatment with either endovascular or open repair is reasonable and depends on degree of injury, aortic anatomy, and the patient’s overall clinical status (Class 2a) Grade 1Intimal tear, defect, or thrombus < 10mm it may be reasonable to consider repair to reduce risk of progression to life-threatening injury (Class 2b) Aortic Injury Zones. Some Zone 1 and 3 injuries are typically amenable to endovascular approaches, while Zone 2 injuries are not. if associated with malperfusion, it is reasonable to consider repair (Class 2a) Repair should be performed to address life-threatening aortic injury (Class 1) The usefulness of routine application of REBOA for hemorrhage control is unclear and in some cases may cause harm. (Class 3:Harm) Grade 2Intimal tear, defect, or thrombus ≥10mm Grade 3Pseudoaneurysm Grade 3Aortic rupture Anti-impulse therapy if tolerated and repeat imaging in 24-48 hours (Class 1) Abbreviations: REBOA indicates resuscitative endovascular balloon occlusion of the aorta. 24
Slide 25-

Long Term Surveillance and Management following Acute Aortic Syndrome Aortic Dissection or Intramural Hematoma Open or Endovascular Repair Medical Therapy Surveillance imaging at appropriate intervals for repair; if residual aortic disease remains unrepaired then CT or MRI at 1 month, 6 months, 12 months, and if stable then annually thereafter (Class 1) Whether initially treated medically or with intervention, who have chronic residual TAD and an aneurysm with a total aortic diameter of >5.5 cm, elective thoracic aortic repair is recommended (Class 1) CT or MRI at 1 month, 6 months, 12 months, and if stable then annually thereafter (Class 1) Penetrating Aortic Ulcer (PAU)* Repair Medical Therapy Surveillance imaging at appropriate intervals for repair is reasonable (Class 2a) CT is reasonable at 1 month and if stable, every 6 months for 2 years then at appropriate intervals thereafter (Class 2a) * 46% of PAUs progress to dissection or intramural hematoma after mean 12 months Abbreviations: cm indicates centimeter; CT, computed tomography; MRI, magnetic resonance imaging; PAU, penetrating atherosclerotic ulcer; and TAD, thoracic aortic disease. 25
Slide 26-

Counseling and Management of Aortic Disease in Pregnancy and Postpartum Prepregnancy During Pregnancy Delivery Abbreviations: AoD indicates aortic dissection; BAV, bicuspid aortic valve; cm, centimeter; CT, computed tomography; HTAD, heritable thoracic aortic diseases; LDS, Loeys-Dietz Syndrome; MFS, Marfan Syndrome; MRI, magnetic resonance imaging; TTE, transthoracic echocardiography; TS, Turner Syndrome; and vEDS, Vascular Ehlers-Danlos Syndrome. 26
Slide 27-

Diagnosis and Management of Inflammatory Aortitis Diagnostic Criteria TAK (≥3) criteria present Age <40Y Claudication ↓Brachial Pulse SCA/aortic bruit SBP variation ≥10mmHg in arms Aortic or aortic branch stenosis GCA (≥3) criteria present Age >50y New localize headache Temporal artery tenderness or ↓ pulse ESR >50mm/h (+) Necrotizing vasculitis on arterial bx Systemic Therapy GCA + active aortitis: Tocilizumab is recommended as adjunctive therapy to glucocorticoids, with methotrexate as an alternative (Class 1) TAK: non-biological disease-modifying anti-rheumatic drugs (e.g., methotrexate, hydroxychloroquine, azathioprine, sulfamethoxazole, and leflunomide) should be given in combination with glucocorticoids (Class 1) Imaging / Monitoring TAK or GCA Patients: Initial MRI or CT +/- PET entire aorta and branches ( Class 1) Monitor treatment efficacy with periodic serum inflammatory markers (CRP/ESR) and repeat imaging (Class 1) Annual surveillance imaging for GCA/TAK patients in remission (MRI/CT/PET) (Class 2a) Surgery Elective (open or endovascular) surgical intervention to treat aortic and/or branch vessel complications is reasonable for GCA/TAK patients in remission (Class 2a) Abbreviations: CT indicates computed tomography; ESR, erythrocyte sedimentation rate; GCA, giant cell arteritis; h, hour; mg, milligram; MRI, magnetic resonance imaging; PET, positron emission tomography; SCA, subclavian artery; TAK, Takayasu arteritis and y, year. 27 Initial therapy for active GCA/TAK: High-dose glucocorticoid (Class 1) (prednisone 40-60mg/day or equivalent)
Slide 28-

Diagnosis and Management of Infection of the Native Aorta Individualized approach for each patient based on location, clinical status, surgical risk 28
Slide 29-

Following operative treatment, ID consultation and at least 6 weeks of targeted intravenous antimicrobial+/- prolonged oral suppressive therapy is recommended (Class 1) Diagnosis and Management of Prosthetic Aortic Graft Infection Suspected aortic graft infection Imaging (preferably with CTA) is reasonable to evaluate suspected prosthetic aortic graft infection (Class 2a) Confirmed aortic graft infection Initial Treatment Late Management Hemodynamically Stable Hemodynamically Unstable Unsuitable for open surgery Reasonable to perform open surgery* with either in situ reconstruction or extra-anatomic bypass (Class 2a) Reasonable to perform emergent open surgery* with either explant or native repair and in situ reconstruction (Class 2a) Endovascular therapy is reasonable as bridge for hemodynamic instability or as long-term therapy for unsuitable surgical candidates (Class 2a) Lifelong suppressive antimicrobials may be considered for cases with extensive abscess, MRSA, Pseudomonas aeruginosa, MDROs, or in situ reconstruction (Class 2b) *No clear superiority of cryopreserved allografts, rifampin- or silver-impregnated grafts Abbreviations: CTA indicates computed tomography angiography; ID, infectious diseases; MRSA, methicillin-resistant Staphylococcus aureus; and MDROs, multidrug-resistant organisms. 29
Slide 30-

Aortic Atherosclerotic Disease Associated with coronary artery disease, peripheral arterial disease and all-cause mortality. Associated with embolic complications such as stroke Medical Management of Aortic Atheroma Abbreviations: mm indicates millimeter; and PAD, peripheral arterial disease. 30
Slide 31-

Aortic Thrombus and Occlusion Most asymptomatic but may embolize Primary: Normal or minimally atherosclerotic aorta May be idiopathic or associated with hypercoagulability Often pedunculated and extend into lumen Secondary: Associated with aortic pathology (aneurysm, atheroma, aortitis) Often in descending thoracic and abdominal aorta Aortic Mural Thrombus , Diagnosis: CTA or TEE Treatment: Primary thrombus or embolic events managed with anticoagulation, endovascular intervention, and/or open surgery Secondary to extensive atherosclerosis Typically, below renal arteries Clinical spectrum from acute to chronic occlusion May be asymptomatic if extensive collaterals, commonly presents with claudication symptoms Aortic Occlusion Treatment: Embolectomy for acute embolus OR Revascularization options: endovascular, open aortic, extra-anatomic bypass No RCT evidence for any specific revascularization strategy Abbreviations: CTA indicates computed tomography angiography; RCT, randomized controlled trial; and TEE, transesophageal echocardiography. 31
Slide 32-

Shared-Decision Making Determining appropriate threshold for intervention Deciding on the type of surgical repair Surgical vs endovascular approach Medical management and surveillance Pregnancy (e.g. mode of delivery, threshold for prophylactic surgery) 32
Slide 33-

Coarctation of the Aorta: Recommendations for Diagnosis and Management Criteria for Significant Coarctation Upper extremity hypertension (at rest, on ambulatory BP monitor or with pathologic BP response to exercise) or LVH Non-invasive BP difference >20 mmHg between upper and lower extremities Mean gradient >20 mmHg by echocardiography (or >10 mmHg if decreased LV systolic function or significant collaterals) Peak-to-peak gradient >20 mmHg by catheterization (or >10 mmHg if decreased LV systolic function or significant collaterals) ✚ any 1 of the following: Abbreviations: BP indicates blood pressure; CoA, coarctation of the aorta; CT, computed tomography; HTN, hypertension; LVH, left ventricular hypertrophy; and MRI, magnetic resonance imaging. 33
Slide 34-

Physical Activity and Quality of Life Abbreviations: AAA indicates abdominal aortic aneurysms; and BP, blood pressure. 34
Slide 35-

Cost and Value Considerations for Aortic Aneurysm Repair Aortic AneurysmOpen vs. Endovascular Repair Cost-Effectiveness Endovascular repair associated with … compared to open repair: BENEFITS Lower initial costs for endovascular repair with shorter hospital stay DRAWBACKS Higher long-term costs due to ongoing surveillance and reinterventions Areas for Improvement in Cost-Effectiveness Minimize duplication of diagnostic imaging by using common protocols, imaging platforms, and reduction in redundant clinician visits through coordinated care Abbreviations: AoD indicates aortic dissection. 35
Slide 36-

Evidence Gaps and Future Directions Biomarker Studies Biomarker expression has not been clearly associated with relevant clinical aortic events. Biomarkers can help identify new treatment options for patients with aortic disease. Image based cardiac and aortic markers with machine learning might provide a wealth of information for guiding the optimal care. Genetic and Nongenetic Factors Genetic testing can identify pathogenic mutations in specific genes that increase a patient’s risk of aneurysm and/or dissection aiding in optimal timing of aortic repair. Environmental factors and lifestyle habits may contribute to aortic aneurysm formation. Genetic and Nongenetic Factors Aortic diameter alone is an insufficient predictor of AoD risk. Understanding the distribution of biomechanical wall stress and hemodynamic flow disturbances may improve risk stratification and patient outcomes. Abbreviations: AAA indicates abdominal aortic aneurysm; EVAR, endovascular aneurysm repair; TEVAR, thoracic endovascular aneurysm repair; and TAA, thoracic aortic aneurysm. 36
Slide 37-

Evidence Gaps and Future Directions Abbreviations: HRQOL indicates health-related quality of life.
Slide 38-

Acknowledgments Many thanks to our Guideline Ambassadors who were guided by Dr. Elliott Antman in developing this translational learning product in support of the 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease. Sean Patrick Thomas Murphy, MD Alex Dalal, MD Courtenay Holscher, MD, PhD Clauden Louis, MD, MS, MPH Jessica G.Y. Luc, MD Rebecca Sorber, MD Albert Pedroza, MD The American Heart Association requests this electronic slide deck be cited as follows: Murphy, S. P., Dalal, A. R., Holscher, C., Louis, C., Luc, J. G. Y., Sorber, R., Pedroza, A., Bezanson, J. L., & Antman, E. M. (2022). AHA Clinical Update; Adapted from: 2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic Disease: A Guideline From the American Heart Association [PowerPoint slides]. Retrieved from https://professional.heart.org/en/science-news. 38