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Asthma And Allergy PowerPoint Presentation

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Published on : Jul 06, 2017 | Views : 3095 | Downloads : 26

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Slide 1-

Asthma and Allergy
Slide 2-

Asthma and Allergy Atopy v Allergy Asthma Aeroallergens – indoor & outdoor Occupational allergens
Slide 3-

Atopy The propensity to produce IgE to allergens Demonstrated using Skin prick tests to common inhalant allergens
Slide 4-

Allergen-Antibody interaction
Slide 5-

Prick Test Reagents
Slide 6-

Skin Prick Tests
Slide 7-

ppt slide no 7 content not found
Slide 8-

Allergy IgE mediated inflammatory tissue damage in response to an allergen causing clinical disease
Slide 9-

Asthma - epidemiology X 2- 3 increase last 30 years Concomitant similar increase in atopy, hayfever and eczema ? Environmental Change ? Less infections ( hygiene hypothesis )
Slide 10-

Allergens Outdoor Pollens- Tree Grass Moulds - Alternaria Aspergillus Cladosporium Penicillium
Slide 11-

Allergens Indoor Cat Dog Cockroach Birds
Slide 12-

Inhalation of allergen Immediate response ( IgE mediated ) Max: 20 min. Ends : 60 min. Late response in 50% (Eosinophil ) Onset 3h Max 12 h End 24 h Responsible for airways hyperreactivity Allergen ID and avoidance therefore very important
Slide 13-

Pollenosis and BHR
Slide 14-

Allergic history and negative skin tests Remember grass pollen allergy
Slide 15-

Pollenosis Prof. Paul Potter, Cape Town Big role for grass pollens in respiratory allergy Kikuyu grass Bermuda grass Buffalo grass ( l’herbe bourrique ) SPT regents to detect allergy to these being developed Mauritus has all of these grasses in abundance
Slide 16-

Why study pollens Potential for immunotherapy
Slide 17-

Indoor allergens-avoidance House dust mite allergen Large Not easily air-borne Needs close proximity to bedding to be inhaled
Slide 18-

House dust mite avoidance Mite impermeable mattress covers Hot wash bedding linen ( 55 C ) Remove moquettes Light curtains Vacuum clean with high filtration cleaner
Slide 19-

Mattress Covers
Slide 20-

Vacuum cleaners
Slide 21-

Pet allergens Remove the pet Clean it Remove carpets ( x 100 fold antigen)
Slide 22-

Cat Eviction
Slide 23-

Asthma- none of usual aeroallergens Think of occupational asthma
Slide 24-

Occupational Asthma Asthma initiated by an agent inhaled at work Cf. Work-related asthma Pre-existing asthma provoked by an irritant in the workplace
Slide 25-

Occupational asthma Only a % of workers affected Latent period before onset ( 2 Yr.) Improvement during periods away from work Once established can be triggered by really small doses of antigen
Slide 26-

Usual suspects HMW ( Biologic ) Latex Flour ( 334 ) Laboratory mammals(188) Bacillus subtilis LMW ( haptens ) Colophony ( 175 ) Wood dust Diisocyanates ( 658 ) Platinum salts Acid anhydrides ( 364 ) Glutaraldehyde Plastics workers Bone cement
Slide 27-

Occupational Asthma
Slide 28-

Serial Peak Flow- latex
Slide 29-

Bronchial Provocation Testing
Slide 30-

Inhalation Challenge
Slide 31-

Inhalation Challenge
Slide 32-

Occupational Asthma
Slide 33-

Occupational asthma Diagnosis will have major impact on patient’s life False + ve : needless loss of job False – ve : Needless continuing exposure Be careful
Slide 34-

Thank You Discussion