INFOGRAPHICS : G Protein-coupled Receptors in Drug Discovery Infographic

DESCRIPTION : Checkout “G Protein-coupled Receptors in Drug Discovery” Infographic by technologynetworks.com. Download and go through this infographic to learn about G protein-coupled receptors (GPCRs), GPCR structure and activation, GPCR drug targets and GPCR targeted-therapeutics for a number of disease areas. GPCRs have seven hydrophobic transmembrane domains (yellow). In the presence of an agonist the inactive form (A) is ‘stimulated’ and the receptor conformation changes (B), altering its association with the alpha subunit (Ga) of the neighboring G protein. GDP is exchanged for GTP and the activated G protein alpha subunit dissociates from the beta and gamma subunits (dark purple). The dissociated alpha subunit and beta-gamma dimer are now able to di use laterally within the membrane, interacting with other proteins, stimulating cell signaling pathways.

UPLOADED BY Anupma Singh on Oct 05, 2020 in Pharmaceutical section

TAGS : healthcare | medical | g protein-coupled receptors | gpcrs | gpcr drug targets | medical infographic | healthcare infographic | health infographic

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